anti- CYP3A4 antibody

Product Description

anti- CYP3A4 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified..

Immunogen: cytochrome P450, family 3, subfamily A, polypeptide 4

Synonyms: CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1, cytochrome P450 3A4

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:20 - 1:200; IF: 1:20 - 1:200

Image 1: Immunohistochemistry of paraffin-embedded human liver using FNab02165(CYP3A4 antibody) at dilution of 1:50

Image 2: Immunofluorescent analysis of ( -20? Ethanol ) fixed HepG2 cells using FNab02165 (CYP3A4 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L).

Image 3:

Image 4: rat liver tissue were subjected to SDS PAGE followed by western blot with FNab02165(CYP3A4 antibody) at dilution of 1:1000

Gene ID: 1576

Research Area: Metabolism

Uniprot ID: P08684