anti- DCLRE1C antibody

Product Description

anti- DCLRE1C antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V,(D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks(DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining(NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ..

Immunogen: DNA cross-link repair 1C(PSO2 homolog, S. cerevisiae)

Synonyms: ARTEMIS, ASCID, SCIDA, SNM1C

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab02268(DCLRE1C antibody) at dilution of 1:400

Gene ID: 64421

Research Area: Metabolism

Uniprot ID: Q96SD1