anti- DIABLO antibody

Product Description

anti- DIABLO antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins(IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.This antibody recognizes all the three isoforms of DIABLO..

Immunogen: diablo homolog(Drosophila)

Synonyms: DIABLO, Diablo homolog, mitochondrial, DIABLO S, SMAC, SMAC3

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution: WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human testis using FNab02384(DIABLO antibody) at dilution of 1:50

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab02384(DIABLO antibody) at dilution of 1:1000

Gene ID: 56616

Research Area: Metabolism

Uniprot ID: Q9NR28