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Product Description
anti- Drosha antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Ribonuclease III double-stranded(ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA(miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts(pri-miRNAs) to release precursor miRNA(pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs(processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies..
Immunogen: ribonuclease type III, nuclear
Synonyms: RN3, RNASE3L, RNASEN
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB
Recommended dilution:
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Image 4: HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab02540(Drosha antibody) at dilution of 1:800
Gene ID: 29102
Research Area: Metabolism
Uniprot ID: Q9NRR4
