anti- E2F8 antibody

Product Description

anti- E2F8 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins(E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene..

Immunogen: E2F transcription factor 8

Synonyms:

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IP

Recommended dilution:

Image 1:

Image 2: .

Image 3:

Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab02604(E2F8 antibody) at dilution of 1:1000

Gene ID: 79733

Research Area: Metabolism

Uniprot ID: A0AVK6