anti- ERI1 antibody

Product Description

anti- ERI1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs(siRNAs) in vitro, suggesting a possible role as regulator of RNA interference(RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs..

Immunogen: exoribonuclease 1

Synonyms: 3'EXO, THEX1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human testis using FNab02843(ERI1 antibody) at dilution of 1:50

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Image 4: K-562 cells were subjected to SDS PAGE followed by western blot with FNab02843(ERI1 antibody) at dilution of 1:1000

Gene ID: 90459

Research Area: Metabolism

Uniprot ID: Q8IV48