anti- FBXO9 antibody

Product Description

anti- FBXO9 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Substrate recognition component of a SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1..

Immunogen: F-box protein 9

Synonyms: FBX9, VCIA1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human prostate cancer using FNab03051(FBXO9 antibody) at dilution of 1:50

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Image 4: human liver tissue were subjected to SDS PAGE followed by western blot with FNab03051(FBXO9 antibody) at dilution of 1:300

Gene ID: 26268

Research Area: Metabolism

Uniprot ID: Q9UK97