anti- FEN1 antibody

Product Description

anti- FEN1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions..

Immunogen: flap structure-specific endonuclease 1

Synonyms: RAD2

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IHC, IF, IP

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100; IP : 1:50 - 1:200

Image 1: Immunohistochemistry of paraffin-embedded human lung cancer using FNab03075( FEN1 Antibody) at dilution of 1:100

Image 2: .

Image 3:

Image 4: NIH/3T3 cells were subjected to SDS PAGE followed by western blot with FNab03075(FEN1 antibody) at dilution of 1:1000

Gene ID: 2237

Research Area: Metabolism

Uniprot ID: P39748