anti- FZD5 antibody

Product Description

anti- FZD5 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway..

Immunogen: frizzled homolog 5(Drosophila)

Synonyms: C2orf31

Reactivity: Human

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: COLO 320 cells were subjected to SDS PAGE followed by western blot with FNab03264( FZD5 Antibody) at dilution of 1:600

Gene ID: 7855

Research Area: Metabolism

Uniprot ID: Q13467