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Product Description
anti- GPR161 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown(By similarity)..
Immunogen: G protein-coupled receptor 161
Synonyms:
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC
Recommended dilution:
Image 1: Immunohistochemistry of paraffin-embedded human placenta using FNab03598(GPR161 antibody) at dilution of 1:50
Image 2: .
Image 3:
Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab03598(GPR161 antibody) at dilution of 1:500
Gene ID: 23432
Research Area: Metabolism
Uniprot ID: Q8N6U8
