anti- HELB antibody

Product Description

anti- HELB antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection(PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA(ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB(PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation(PubMed:26774285). Acts independently of TP53BP1(PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates(PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress(PubMed:22194613)..

Immunogen: helicase(DNA) B

Synonyms:

Reactivity: Human

Tested Application: ELISA, WB, IF

Recommended dilution:

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Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03821( HELB Antibody) at dilution of 1:1000

Gene ID: 391723

Research Area: Metabolism

Uniprot ID: Q8NG08