anti- HEY1 antibody

Product Description

anti- HEY1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'(PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3(PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal(PubMed:25985737)..

Immunogen: hairy/enhancer-of-split related with YRPW motif 1

Synonyms: BHLHB31, CHF2, HERP2, HESR1, HRT1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution: WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human brain using FNab03849(HEY1 antibody) at dilution of 1:100

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Image 4: DU 145 cells were subjected to SDS PAGE followed by western blot with FNab03849(HEY1 antibody) at dilution of 1:3000

Gene ID: 23462

Research Area: Metabolism

Uniprot ID: Q9Y5J3