anti- HGS antibody

Product Description

anti- HGS antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body(MVBs) when complexed with STAM(ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation..

Immunogen: hepatocyte growth factor-regulated tyrosine kinase substrate

Synonyms: HRS

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IP, IF

Recommended dilution:

Image 1:

Image 2: .

Image 3:

Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab03853(HGS antibody) at dilution of 1:800

Gene ID: 9146

Research Area: Metabolism

Uniprot ID: O14964