anti- HLA class I(HLA-A) antibody

Product Description

anti- HLA class I(HLA-A) antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described..

Immunogen: major histocompatibility complex, class I, A

Synonyms: HLA A, HLA class I, HLA class I (HLA-A), HLA class I ABC, HLA-A, MHC class I antigen A*3

Reactivity: Human

Tested Application: ELISA, WB, IHC, FC

Recommended dilution: WB: 1:1000-1:8000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab03896(HLA class I(HLA-A) Antibody) at dilution of 1:200

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab03896(HLA class I(HLA-A) Antibody) at dilution of 1:4000

Gene ID: 3105

Research Area: Metabolism

Uniprot ID: P04439/P30443