Product Description
anti- HMGCR antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene..
Immunogen: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Synonyms: HMG CoA reductase, HMGCR, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMDH
Reactivity: Human
Tested Application: ELISA, IHC
Recommended dilution: IHC: 1:20-1:200
Image 1: Immunohistochemistry of paraffin-embedded human colon cancer using FNab10055(HMGCR antibody) at dilution of 1:100
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Gene ID: 3156
Research Area: Metabolism
Uniprot ID: P04035