anti- HNRNPC antibody

Product Description

anti- HNRNPC antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles(PubMed:8264621). Specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs(lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing(PubMed:25719671). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules(PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621)..

Immunogen: heterogeneous nuclear ribonucleoprotein C(C1/C2)

Synonyms: HNRPC

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF, FC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human lymphoma using FNab03949(HNRNPC antibody) at dilution of 1:100

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab03949(HNRNPC antibody) at dilution of 1:500

Gene ID: 3183

Research Area: Metabolism

Uniprot ID: P07910