anti- HNRNPK antibody

Product Description

anti- HNRNPK antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction(By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21(lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest..

Immunogen: heterogeneous nuclear ribonucleoprotein K

Synonyms: HNRPK

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF, FC, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human breast cancer using FNab03955(HNRNPK antibody) at dilution of 1:50

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab03955(HNRNPK antibody) at dilution of 1:300

Gene ID: 3190

Research Area: Metabolism

Uniprot ID: P61978