anti- HTRA1 antibody

Product Description

anti- HTRA1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors(IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets..

Immunogen: HtrA serine peptidase 1

Synonyms: HTRA, PRSS11

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IF, IP, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human placenta tissue slide using FNab04069(HTRA1 Antibody) at dilution of 1:200

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Image 4: L02 cells were subjected to SDS PAGE followed by western blot with FNab04069(HTRA1 antibody) at dilution of 1:600

Gene ID: 5654

Research Area: Metabolism

Uniprot ID: Q92743