anti- HUS1 antibody

Product Description

anti- HUS1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants..

Immunogen: HUS1 checkpoint homolog (S. pombe)

Synonyms:

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IHC, WB

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Image 1: Immunohistochemistry of paraffin-embedded human uterine cancer using FNab04082(HUS1 antibody) at dilution of 1:50

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Image 4: BxPC-3 cells were subjected to SDS PAGE followed by western blot with FNab04082(HUS1 antibody) at dilution of 1:0

Gene ID: 3364

Research Area: Metabolism

Uniprot ID: O60921