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Product Description
anti- HUWE1 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta(POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4..
Immunogen: HECT, UBA and WWE domain containing 1
Synonyms: KIAA0312, KIAA1578, UREB1
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB
Recommended dilution: WB: 1:500-1:2000
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Image 4: HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab04084(HUWE1 Antibody) at dilution of 1:1000
Research Area: Metabolism
Uniprot ID: Q7Z6Z7
