anti- IFITM3 antibody

Product Description

anti- IFITM3 antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus(SARS-CoV), Marburg virus(MARV) and Ebola virus(EBOV), Dengue virus(DNV), West Nile virus(WNV), human immunodeficiency virus type 1(HIV-1) and vesicular stomatitis virus(VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase(v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.This antibody recognizes both IFITM2 and IFITM3..

Immunogen: IFITM2/3 fusion protein

Synonyms: 1 8U, IFITM3, IP15

Reactivity: Human

Tested Application: ELISA, WB, IF, IHC, FC

Recommended dilution: WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Image 1: Immunohistochemistry of paraffin-embedded human lung cancer using FNab04145(IFITM3 antibody) at dilution of 1:50

Image 2: Immunofluorescent analysis of HepG2 cells, using IFITM3 antibody FNab04145 at 1:25 dilution and Rhodamine-labeled goat anti-mouse IgG (red).

Image 3:

Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab04145(IFITM3 antibody) at dilution of 1:1000

Gene ID: 10410

Research Area: Metabolism

Uniprot ID: Q01628