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Product Description
anti- INSIG1 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins(SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation(ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth..
Immunogen: insulin induced gene 1
Synonyms:
Reactivity: Human, Mouse
Tested Application: ELISA, WB, IF, IHC, IP
Recommended dilution:
Image 1: Immunohistochemistry of paraffin-embedded human liver using FNab04333(INSIG1 antibody) at dilution of 1:50
Image 2: .
Image 3:
Image 4: A549 cells were subjected to SDS PAGE followed by western blot with FNab04333(INSIG1 antibody) at dilution of 1:1000
Gene ID: 3638
Research Area: Metabolism
Uniprot ID: O15503
