anti- INTS3 antibody

Product Description

anti- INTS3 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs(snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain(CTD) of RNA polymerase II largest subunit(POLR2A) and is recruited to the U1 and U2 snRNAs genes. Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks(DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites..

Immunogen: integrator complex subunit 3

Synonyms: C1orf193, C1orf60

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IP

Recommended dilution:

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab04361(INTS3 antibody) at dilution of 1:500

Gene ID: 65123

Research Area: Metabolism

Uniprot ID: Q68E01