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Product Description
anti- INVS antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled(DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8(By similarity). Does not seem to be strictly required for ciliogenesis(By similarity)..
Immunogen: inversin
Synonyms: INV, NPHP2
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC, IF
Recommended dilution:
Image 1: Immunohistochemistry of paraffin-embedded human breast cancer using FNab04369(INVS antibody) at dilution of 1:100
Image 2: .
Image 3:
Image 4: MCF7 cells were subjected to SDS PAGE followed by western blot with FNab04369(INVS antibody) at dilution of 1:100
Gene ID: 27130
Research Area: Metabolism
Uniprot ID: Q9Y283
