anti- IPO13 antibody

Product Description

anti- IPO13 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex(NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus(By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13..

Immunogen: importin 13

Synonyms: KIAA0724, RANBP13

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human gliomas using FNab04374(IPO13 antibody) at dilution of 1:50

Image 2: .

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Image 4: human brain tissue were subjected to SDS PAGE followed by western blot with FNab04374(IPO13 antibody) at dilution of 1:500

Gene ID: 9670

Research Area: Metabolism

Uniprot ID: O94829