anti- KCNA5 antibody

Product Description

anti- KCNA5 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel(PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation(PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation(PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation(PubMed:11524461)..

Immunogen: potassium voltage-gated channel, shaker-related subfamily, member 5

Synonyms:

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab04477( KCNA5 Antibody) at dilution of 1:600

Gene ID: 3741

Research Area: Metabolism

Uniprot ID: P22460