anti- KLHL12 antibody

Product Description

anti- KLHL12 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Substrate-specific adapter of a BCR(BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem(ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31(SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4..

Immunogen: kelch-like 12(Drosophila)

Synonyms: C3IP1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human testis using FNab04610(KLHL12 antibody) at dilution of 1:100

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Image 4: PC-3 cells were subjected to SDS PAGE followed by western blot with FNab04610(KLHL12 antibody) at dilution of 1:1000

Gene ID: 59349

Research Area: Metabolism

Uniprot ID: Q53G59