anti- KPNA2 antibody

Product Description

anti- KPNA2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex(NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and-beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus..

Immunogen: karyopherin alpha 2(RAG cohort 1, importin alpha 1)

Synonyms: RCH1, SRP1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab04635(KPNA2 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab04635(KPNA2 antibody) at dilution of 1:1000

Gene ID: 3838

Research Area: Metabolism

Uniprot ID: P52292