anti- LEF1 antibody

Product Description

anti- LEF1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1(By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells..

Immunogen: lymphoid enhancer-binding factor 1

Synonyms:

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IHC, WB, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human thymus using FNab04745(LEF1 antibody) at dilution of 1:100

Image 2: .

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Image 4: COLO 320 cells were subjected to SDS PAGE followed by western blot with FNab04745(LEF1 Antibody) at dilution of 1:300

Gene ID: 51176

Research Area: Metabolism

Uniprot ID: Q9UJU2