anti- LGR5 antibody

Product Description

anti- LGR5 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development..

Immunogen: leucine-rich repeat-containing G protein-coupled receptor 5

Synonyms: FEX, G protein coupled receptor 49, G protein coupled receptor 67, GPR49, GPR67, GRP49, HG38, LGR5

Reactivity: Human

Tested Application: ELISA, IHC

Recommended dilution: IHC: 1:100-1:400

Image 1: Immunohistochemical of paraffin-embedded human small intestine using FNab04765(LGR5 antibody) at dilution of 1:200

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Gene ID: 8549

Research Area: Metabolism

Uniprot ID: O75473