anti- LIN28B antibody

Product Description

anti- LIN28B antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Suppressor of microRNA(miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts(pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA(PubMed:22118463). Does not act on pri-miR21(PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation(PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent(PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression(By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth..

Immunogen: lin-28 homolog B(C. elegans)

Synonyms: CSDD2

Reactivity: Human, Mouse

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: mouse embryo tissue were subjected to SDS PAGE followed by western blot with FNab04785(LIN28B antibody) at dilution of 1:300

Gene ID: 389421

Research Area: Metabolism

Uniprot ID: Q6ZN17