anti- MAP4K2 antibody

Product Description

anti- MAP4K2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase(MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase(SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns(PAMPs) such as polyinosine-polycytidine(poly(IC)), lipopolysaccharides(LPS), lipid A, peptidoglycan(PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion..

Immunogen: mitogen-activated protein kinase kinase kinase kinase 2

Synonyms: GCK, RAB8IP

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab04981(MAP4K2 antibody) at dilution of 1:300

Gene ID: 5871

Research Area: Metabolism

Uniprot ID: Q12851