anti- MARK2 antibody

Product Description

anti- MARK2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins(DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells..

Immunogen: MAP/microtubule affinity-regulating kinase 2

Synonyms: EMK1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human prostate cancer using FNab05013(MARK2 antibody) at dilution of 1:50

Image 2: .

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Image 4: mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab05013(MARK2 antibody) at dilution of 1:1000

Gene ID: 2011

Research Area: Metabolism

Uniprot ID: Q7KZI7