anti- MCC antibody

Product Description

anti- MCC antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase(PAK) activation(PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway(canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin(CTNB1) transcriptional activity(PubMed:24824780)..

Immunogen: mutated in colorectal cancers

Synonyms:

Reactivity: Human, Mouse

Tested Application: ELISA, IHC, IP, WB, IF

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human prostate cancer using FNab05046(MCC antibody) at dilution of 1:100

Image 2: .

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Image 4: human brain tissue were subjected to SDS PAGE followed by western blot with FNab05046(MCC antibody) at dilution of 1:500

Gene ID: 4163

Research Area: Metabolism

Uniprot ID: P23508