anti- MECP2 antibody

Product Description

anti- MECP2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms..

Immunogen: methyl CpG binding protein 2 (Rett syndrome)

Synonyms: AUTSX3

Reactivity: Human, Mouse

Tested Application: ELISA, IHC, WB

Recommended dilution: WB: 1:500 - 1:1000; IHC: 1:50 - 1:100

Image 1: Immunohistochemistry of paraffin-embedded human gastric cancer using FNab05082(MECP2 antibody) at dilution of 1:50

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Image 4: MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with FNab05082(MECP2 Antibody) at dilution of 1:1000

Gene ID: 4204

Research Area: Metabolism

Uniprot ID: P51608