anti- MFN2 antibody

Product Description

anti- MFN2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy(mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response(UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions..

Immunogen: mitofusin 2

Synonyms: CMT2A, CMT2A2, CPRP1, HSG, KIAA0214, MARF, MFN2, Mitofusin 2, Transmembrane GTPase MFN2

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IP, IHC

Recommended dilution: IP: 1:200-1:1000; WB: 1:200-1:1000; IHC: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human heart tissue slide using FNab05151(MFN2 Antibody) at dilution of 1:200

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Image 4: mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab05151(MFN2 antibody) at dilution of 1:500

Gene ID: 9927

Research Area: Metabolism

Uniprot ID: O95140