anti- MMP12 antibody

Product Description

anti- MMP12 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: MMP12(Matrix metalloproteinase-12) is a 54 kDa proenzyme that is processed into a 45 kDa and then a 22 kDa active form(15723202). MMP9 and MMP12 promote intimal thickening by independent cleavage of N-cadherin, which elevates vascular smooth muscle cell proliferation via beta-catenin signalling. Its overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis(PMID: 21378275)..

Immunogen: matrix metallopeptidase 12(macrophage elastase)

Synonyms: HME, Macrophage elastase, Macrophage metalloelastase, Matrix metalloproteinase 12, ME, MME, MMP 12, MMP12

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

Image 1: Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab05234(MMP12 Antibody) at dilution of 1:50

Image 2: Immunofluorescent analysis of ( -20? Ethanol ) fixed A549 cells using FNab05234 (MMP12 antibody) at dilution of 1:25 and Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L).

Image 3:

Image 4: mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab05234(MMP12 Antibody) at dilution of 1:600

Gene ID: 4321

Research Area: Metabolism

Uniprot ID: P39900