anti- MTF2 antibody

Product Description

anti- MTF2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Polycomb group(PcG) that specifically binds histone H3 trimethylated at 'Lys-36'(H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element(MRE) of MT1A gene promoter(By similarity)..

Immunogen: metal response element binding transcription factor 2

Synonyms: PCL2

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human brain using FNab05397(MTF2 antibody) at dilution of 1:50

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Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab05397(MTF2 antibody) at dilution of 1:600

Gene ID: 22823

Research Area: Metabolism

Uniprot ID: Q9Y483