anti- NANOG antibody

Product Description

anti- NANOG antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Transcription regulator involved in inner cell mass and embryonic stem(ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating(ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation..

Immunogen: Nanog homeobox

Synonyms:

Reactivity: Human, Mouse

Tested Application: ELISA, IF, WB

Recommended dilution:

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Image 4: rat brain tissue were subjected to SDS PAGE followed by western blot with FNab05541( NANOG Antibody) at dilution of 1:2000

Gene ID: 79923

Research Area: Metabolism

Uniprot ID: Q9H9S0