anti- NDFIP1 antibody

Product Description

anti- NDFIP1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation(By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity(PubMed:19706893). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate(PubMed:20534535). Enhances the ubiquitination of BRAT1 mediated by E3 ubiquitin-protein ligases: NEDD4, NEDD4L and ITCH, and is required for the nuclear localization of ubiquitinated BRAT1(PubMed:25631046)..

Immunogen: Nedd4 family interacting protein 1

Synonyms: N4WBP5

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IP, WB, IF

Recommended dilution:

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Image 4: HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab05602( NDFIP1 Antibody) at dilution of 1:300

Gene ID: 80762

Research Area: Metabolism

Uniprot ID: Q9BT67