anti- NEIL3 antibody

Product Description

anti- NEIL3 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: DNA glycosylase which prefers single-stranded DNA(ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA(dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin(Sp) and guanidinohydantoin(Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair..

Immunogen: nei endonuclease VIII-like 3(E. coli)

Synonyms:

Reactivity: Human, Mouse

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab05649(NEIL3 antibody) at dilution of 1:500

Gene ID: 55247

Research Area: Metabolism

Uniprot ID: Q8TAT5