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Product Description
anti- NGEF antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Acts as a guanine nucleotide exchange factor(GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension(By similarity)..
Immunogen: neuronal guanine nucleotide exchange factor
Synonyms:
Reactivity: Human, Mouse
Tested Application: ELISA, WB, IP, IHC
Recommended dilution: WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:50-1:500
Image 1: Immunohistochemistry of paraffin-embedded human brain tissue slide using FNab05720( NGEF antibody) at dilution of 1:200
Image 2: .
Image 3:
Image 4: mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab05720(NGEF antibody) at dilution of 1:500
Gene ID: 25791
Research Area: Metabolism
Uniprot ID: Q8N5V2
