anti- NR2F6 antibody

Product Description

anti- NR2F6 antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and-independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements(TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus(LC)..

Immunogen: nuclear receptor subfamily 2, group F, member 6

Synonyms: EAR 2, EAR2, ERBAL2, NR2F6, V erbA related protein 2

Reactivity: Human

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:1000-1:4000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human kidney using FNab05845(NR2F6 antibody) at dilution of 1:50

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Image 4: Hela cells were subjected to SDS PAGE followed by western blot with FNab05845(NR2F6 Antibody) at dilution of 1:2000

Gene ID: 2063

Research Area: Metabolism

Uniprot ID: P10588