anti- NRF2, NFE2L2 antibody

Product Description

anti- NRF2, NFE2L2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response(ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.The expression of NRF2 may be induced under oxidative stress(PMID:14567983).In lung cancer, Nrf2 activation in malignant cells has been associated with tumor progression and chemotherapy resistance(PMID:20534738). Identifying patients with abnormal NRF2 expression may be important for selection for chemotherapy in NSCLC..

Immunogen: nuclear factor(erythroid-derived 2)-like 2

Synonyms: HEBP1, NF E2 related factor 2, NFE2 related factor 2, NFE2L2, NRF2

Reactivity: Human, Mouse, Rat, Zebrafish

Tested Application: ELISA, IP, WB, IHC, FC

Recommended dilution: WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human ovary tumor tissue slide using FNab05855(NRF2, NFE2L2 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

Image 2: .

Image 3: IP Result of anti-NRF2, NFE2L2 (IP: FNab05855, 3ug; Detection: FNab05855 1:300) with mouse kidney tissue lysate 4000ug.

Image 4: DMSO treated HeLa cells were subjected to SDS PAGE followed by western blot with FNab05855(NRF2, NFE2L2 Antibody) at dilution of 1:600

Gene ID: 4780

Research Area: Metabolism

Uniprot ID: Q16236