anti- OAS1 antibody

Product Description

anti- OAS1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L(RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus(VSV), herpes simplex virus type 2(HSV-2), and encephalomyocarditis virus(EMCV) and stimulates the alternative antiviral pathway independent of RNase L..

Immunogen: 2',5'-oligoadenylate synthetase 1, 40/46kDa

Synonyms: OIAS

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human liver tissue slide using FNab05949(OAS1 Antibody) at dilution of 1:200

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab05949(OAS1 antibody) at dilution of 1:500

Gene ID: 4938

Research Area: Metabolism

Uniprot ID: P00973