anti- OPTN antibody

Product Description

anti- OPTN antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin(HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor(TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria(xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death..

Immunogen: optineurin

Synonyms: FIP2, GLC1E, HIP7, HYPL, NRP

Reactivity: Human

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using FNab06000( OPTN Antibody) at dilution of 1:200

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Image 4: human heart tissue were subjected to SDS PAGE followed by western blot with FNab06000( OPTN Antibody) at dilution of 1:1000

Gene ID: 10133

Research Area: Metabolism

Uniprot ID: Q96CV9