anti- OSBP antibody

Product Description

anti- OSBP antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate(PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum(PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol(PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly(PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability(PubMed:18450749)..

Immunogen: oxysterol binding protein

Synonyms: OSBP1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human ovary tumor using FNab06016(OSBP antibody) at dilution of 1:50

Image 2: .

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab06016(OSBP antibody) at dilution of 1:800

Gene ID: 5007

Research Area: Metabolism

Uniprot ID: P22059