anti- OTUD7B antibody

Product Description

anti- OTUD7B antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin..

Immunogen: OTU domain containing 7B

Synonyms: ZA20D1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human kidney using FNab06043(OTUD7B antibody) at dilution of 1:50

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Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab06043(OTUD7B antibody) at dilution of 1:800

Gene ID: 56957

Research Area: Metabolism

Uniprot ID: Q6GQQ9