anti- p65/RELA antibody

Product Description

anti- p65/RELA antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Nuclear factor k B(NF-kB) is a sequence-specific DNA-binding protein complex which regulates the expression of viral genomes, including the human immunodeficiency virus, and a variety of cellular genes, particularly those involved in immune and inflammatory responses. The members of the NF-Kb family in mammalian cells include the proto-oncogene c-Rel,p50/p105(NFkB1), p65(RelA), p52/p100(NFkB2), and RelB. All of these proteins share a conserved 300-amino acid region known as the Rel homology domain which is responsible for DNA binding, dimerization, and nuclear translocation of NF-Kb. The p65 subunit is a major component of NF-Kb complexes and is responsible for trans-activation. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. It associates with chromatin at the NF-kappa-B promoter region via association with DDX1..

Immunogen: v-rel reticuloendotheliosis viral oncogene homolog A(avian)

Synonyms: NFKB 3, NFKB p65, NFKB3, p65, RELA, Transcription factor p65

Reactivity: Human, Rat

Tested Application: ELISA, IHC, IF, WB

Recommended dilution: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200

Image 1: Immunohistochemistry of paraffin-embedded rat lung using FNab09875(p65 antibody) at dilution of 1:50

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab09875(p65 antibody) at dilution of 1:500

Gene ID: 5970

Research Area: Metabolism

Uniprot ID: Q04206