anti- PABPC4 antibody

Product Description

anti- PABPC4 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene..

Immunogen: poly(A) binding protein, cytoplasmic 4 (inducible form)

Synonyms: APP1, PABP4

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100

Image 1: Immunohistochemistry of paraffin-embedded human esophagus using FNab06098(PABPC4 antibody) at dilution of 1:100

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Image 4: mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab06098(PABPC4 antibody) at dilution of 1:1000

Gene ID: 8761

Research Area: Metabolism

Uniprot ID: Q13310